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Orotic acid by Alois C̆ihák

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Published by MTP Press in Lancaster, Eng .
Written in English

Subjects:

  • Orotic acid -- Physiological effect.,
  • Orotic acid -- Metabolism.,
  • Pyrimidines -- Metabolism.

Book details:

Edition Notes

Bibliography: p. 49-114.

StatementAlois C̆ihák and Werner Reutter.
ContributionsReutter, Werner, 1937- joint author.
Classifications
LC ClassificationsQP801.O74 C53
The Physical Object
Paginationvii, 118 p. :
Number of Pages118
ID Numbers
Open LibraryOL4233267M
ISBN 100852002947
LC Control Number80513760

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Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction Brand: A Cihak; W Reutter. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro­ cesses, mentioned in Chapters 8 and 9. Orotic acid is a compound typically used as a mineral carrier to increase bioavailability. As an athletic supplement, it may improve endurance, promote muscle growth, and speed up workout recovery. As a dietary supplement, take mg (1/4 tsp) to mg (1/2 tsp) daily, or as directed by a physician/5(3).

OROT: Urinary excretion of orotic acid, an intermediate in pyrimidine biosynthesis, is increased in many urea cycle disorders and in a number of other disorders involving the metabolism of arginine. The determination of orotic acid can be useful to distinguish between various causes of elevated ammonia (hyperammonemia). Hyperammonemia is characteristic of all urea cycle disorders, but orotic. Orotic aciduria is a disease caused by an enzyme deficiency resulting in a decreased ability to synthesize pyrimidines. It is the only known enzyme deficiency of the de novo pyrimidine synthesis pathway. Orotic aciduria is characterized by excessive excretion of orotic acid in urine because of the inability to convert orotic acid to UMP. It causes megaloblastic anemia and may be associated with Causes: Autosomal recessive mutation of the UMPS gene.   Read "Orotic Acid Synthesis, Biochemical Aspects and Physiological Role" by A. Cihák available from Rakuten Kobo. This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's mil Brand: Springer Netherlands. The urinary excretion of orotic acid, an intermediate in pyrimidine biosynthesis, is increased in many urea cycle disorders and in a number of other disorders involving the metabolism of arginine. The determination of orotic acid can be useful to distinguish between various causes of elevated ammonia (hyperammonemia).

Orotic Acid Orotic acid is a toxic chemical that can lead to hepatic lipidosis in rats via a different mechanism. From: Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition),   The Irony with Vitamin B13 (Orotic Acid) is found in the following statement: “Vitamin B13 is not really recognized as a vitamin, since it is manufactured by the body by intestinal flora.” If you try to find information regarding Vitamin B13, this is usually the first sentence you will encounter. Now, on the surface, I am in full agreement Reviews: 2. Orotic acid, also known as Vitamin B13, is a fast-growing health supplement ingredient for its effects not only in enhancing absorption of nutrients but also in promoting weight loss and lean muscle mass development. Despite the name, Vitamin B13 is not actually considered as a vitamin as it is produced naturally by intestinal flora. IUPAC Standard InChIKey: PXQPEWDEAKTCGB-UHFFFAOYSA-N CAS Registry Number: Chemical structure: This structure is also available as a 2d Mol file; Other names: 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-; Animal galactose factor; Orodin; Oropur; Orotonin; Orotonsan; Oroturic; Orotyl; Whey factor; 2,6-Dihydroxypyrimidinecarboxylic acid; 6-Carboxyuracil; 6.